Drug interactions
Sulphasalazine + Tafamidis
Severity: Moderate
Sulphasalazine and Tafamidis: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafamidis inhibits BCRP in vitro, and sulfasalazine is a sensitive BCRP substrate. Co-administration may increase sulfasalazine exposure and dose-related adverse effects.
What this interaction means in plain words
Sulphasalazine and Tafamidis can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sulphasalazine belongs to Gastrointestinal Tract; Tafamidis belongs to Cardiovascular.
Why it happens
Tafamidis inhibits BCRP-mediated efflux of sulfasalazine, increasing its systemic exposure.
What to do
Monitor for sulfasalazine adverse effects such as GI upset, rash and cytopenias. Reduce the sulfasalazine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Acetazolamide + Sulphasalazine Moderate
Other interactions of Tafamidis
- Apixaban + Tafamidis Moderate
- Atorvastatin + Tafamidis Moderate
- Methotrexate + Tafamidis Moderate
- Mitoxantrone + Tafamidis Moderate
- Pitavastatin + Tafamidis Moderate
- Rivaroxaban + Tafamidis Moderate
Frequently asked questions
Can I take Sulphasalazine with Tafamidis?
MediHelp rates the interaction as moderate. Sulphasalazine and Tafamidis can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tafamidis inhibits BCRP in vitro, and sulfasalazine is a sensitive BCRP substrate. Co-administration may increase sulfasalazine exposure and dose-related adverse effects.
How serious is the interaction between Sulphasalazine and Tafamidis?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sulfasalazine adverse effects such as GI upset, rash and cytopenias. Reduce the sulfasalazine dose if needed.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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