Drug interactions
Sumatriptan intranasal + Tedizolid
Severity: Moderate
Sumatriptan intranasal and Tedizolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sumatriptan is a 5-HT1B/1D agonist, and triptans combined with MAO inhibitors can raise serotonergic toxicity and sumatriptan exposure. Tedizolid is a weak MAO inhibitor, so the risk is likely lower than with stronger MAO inhibitors.
What this interaction means in plain words
Sumatriptan intranasal and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Potential serotonergic additive effect and reduced sumatriptan metabolism via weak MAO-A inhibition.
What to do
Monitor for serotonin syndrome symptoms and avoid repeated or high doses of sumatriptan. Consider an alternative migraine treatment during tedizolid therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Frequently asked questions
Can I take Sumatriptan intranasal with Tedizolid?
MediHelp rates the interaction as moderate. Sumatriptan intranasal and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sumatriptan is a 5-HT1B/1D agonist, and triptans combined with MAO inhibitors can raise serotonergic toxicity and sumatriptan exposure. Tedizolid is a weak MAO inhibitor, so the risk is likely lower than with stronger MAO inhibitors.
How serious is the interaction between Sumatriptan intranasal and Tedizolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome symptoms and avoid repeated or high doses of sumatriptan. Consider an alternative migraine treatment during tedizolid therapy.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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