Drug interactions
Sumatriptan intranasal + Trazodone
Severity: Moderate
Sumatriptan intranasal and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents act on serotonin pathways, and concurrent use has been associated with serotonin syndrome in case reports, though the absolute risk appears low.
What this interaction means in plain words
Sumatriptan intranasal and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects via 5-HT1B/1D agonism and trazodone's serotonergic activity.
What to do
Counsel patients on serotonin syndrome symptoms and monitor, especially at initiation or dose increases. Stop the drugs if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Sumatriptan intranasal with Trazodone?
MediHelp rates the interaction as moderate. Sumatriptan intranasal and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents act on serotonin pathways, and concurrent use has been associated with serotonin syndrome in case reports, though the absolute risk appears low.
How serious is the interaction between Sumatriptan intranasal and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on serotonin syndrome symptoms and monitor, especially at initiation or dose increases. Stop the drugs if symptoms develop.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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