Drug interactions
Sumatriptan intranasal + Vortioxetine
Severity: Moderate
Sumatriptan intranasal and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans combined with serotonergic antidepressants have been linked to serotonin syndrome, although the risk appears low. The combination is often used in practice when both are clinically needed.
What this interaction means in plain words
Sumatriptan intranasal and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects via 5-HT1B/1D agonism and vortioxetine serotonin reuptake inhibition.
What to do
Monitor for serotonin syndrome symptoms, particularly when starting or increasing doses, and counsel the patient to seek care if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Sumatriptan intranasal with Vortioxetine?
MediHelp rates the interaction as moderate. Sumatriptan intranasal and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptans combined with serotonergic antidepressants have been linked to serotonin syndrome, although the risk appears low. The combination is often used in practice when both are clinically needed.
How serious is the interaction between Sumatriptan intranasal and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome symptoms, particularly when starting or increasing doses, and counsel the patient to seek care if they occur.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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