Drug interactions
Sunitinib + Tipranavir
Severity: Major
Sunitinib and Tipranavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted tipranavir strongly inhibits CYP3A4 and may substantially raise sunitinib levels, increasing toxicity including QT prolongation. Tipranavir itself also induces enzymes in some pathways, making the net effect variable.
What this interaction means in plain words
Sunitinib and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sunitinib belongs to Oncology; Tipranavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition by tipranavir/ritonavir reduces sunitinib clearance, with additive QT effects.
What to do
Use an alternative antiretroviral if possible. If combined, reduce the sunitinib dose and monitor ECG and for adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Sunitinib with Tipranavir?
MediHelp rates the interaction as major. Sunitinib and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir-boosted tipranavir strongly inhibits CYP3A4 and may substantially raise sunitinib levels, increasing toxicity including QT prolongation. Tipranavir itself also induces enzymes in some pathways, making the net effect variable.
How serious is the interaction between Sunitinib and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antiretroviral if possible. If combined, reduce the sunitinib dose and monitor ECG and for adverse effects.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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