Drug interactions
Sunitinib + Trastuzumab deruxtecan
Severity: Moderate
Sunitinib and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause neutropenia and other cytopenias, so combined use may increase infection risk. Trastuzumab deruxtecan also carries risks of interstitial lung disease and reduced left ventricular function, which overlaps with sunitinib cardiotoxicity.
What this interaction means in plain words
Sunitinib and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sunitinib belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppressive and cardiotoxic effects (pharmacodynamic).
What to do
Monitor complete blood counts and for infection, and assess left ventricular ejection fraction periodically. Adjust or hold doses per labeling for severe neutropenia or cardiac dysfunction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Sunitinib with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Sunitinib and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause neutropenia and other cytopenias, so combined use may increase infection risk. Trastuzumab deruxtecan also carries risks of interstitial lung disease and reduced left ventricular function, which overlaps with sunitinib cardiotoxicity.
How serious is the interaction between Sunitinib and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and for infection, and assess left ventricular ejection fraction periodically. Adjust or hold doses per labeling for severe neutropenia or cardiac dysfunction.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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