Drug interactions
Sunitinib + Voriconazole
Severity: Major
Sunitinib and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib can prolong the QT interval and voriconazole has a similar effect. Voriconazole also inhibits CYP3A4, which may raise sunitinib concentrations and further increase the arrhythmia risk.
What this interaction means in plain words
Sunitinib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sunitinib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation combined with CYP3A4 inhibition by voriconazole that reduces sunitinib clearance.
What to do
Prefer an antifungal with weaker CYP3A4 inhibition and less QT effect. If coadministered, monitor ECG and electrolytes and consider reducing the sunitinib dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Sunitinib with Voriconazole?
MediHelp rates the interaction as major. Sunitinib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sunitinib can prolong the QT interval and voriconazole has a similar effect. Voriconazole also inhibits CYP3A4, which may raise sunitinib concentrations and further increase the arrhythmia risk.
How serious is the interaction between Sunitinib and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antifungal with weaker CYP3A4 inhibition and less QT effect. If coadministered, monitor ECG and electrolytes and consider reducing the sunitinib dose.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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