Drug interactions
Suvorexant + Voriconazole
Severity: Major
Suvorexant and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Suvorexant is cleared mainly by CYP3A4, and strong inhibitors markedly increase its exposure. This can cause excessive next-day somnolence, impaired driving, and CNS depression.
What this interaction means in plain words
Suvorexant and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Suvorexant belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4, decreasing suvorexant clearance.
What to do
Avoid the combination and use an alternative hypnotic if an azole is needed. If it cannot be avoided, use the lowest suvorexant dose and warn about daytime sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Suvorexant
Frequently asked questions
Can I take Suvorexant with Voriconazole?
MediHelp rates the interaction as major. Suvorexant and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Suvorexant is cleared mainly by CYP3A4, and strong inhibitors markedly increase its exposure. This can cause excessive next-day somnolence, impaired driving, and CNS depression.
How serious is the interaction between Suvorexant and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative hypnotic if an azole is needed. If it cannot be avoided, use the lowest suvorexant dose and warn about daytime sedation.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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