Drug interactions
Tacrolimus + Telavancin
Severity: Moderate
Tacrolimus and Telavancin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and both can harm the kidneys. Combined use may raise the risk of arrhythmia, and renal impairment can further increase tacrolimus exposure.
What this interaction means in plain words
Tacrolimus and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tacrolimus belongs to Miscellaneous; Telavancin belongs to Anti Bacterial.
Why it happens
Additive QTc prolongation, with additive nephrotoxicity that may raise tacrolimus levels.
What to do
Monitor ECG, serum creatinine and tacrolimus trough levels during co-treatment. Correct potassium and magnesium and adjust the tacrolimus dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Tacrolimus with Telavancin?
MediHelp rates the interaction as moderate. Tacrolimus and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and both can harm the kidneys. Combined use may raise the risk of arrhythmia, and renal impairment can further increase tacrolimus exposure.
How serious is the interaction between Tacrolimus and Telavancin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, serum creatinine and tacrolimus trough levels during co-treatment. Correct potassium and magnesium and adjust the tacrolimus dose as needed.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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