Drug interactions
Tacrolimus + Trastuzumab
Severity: Moderate
Tacrolimus and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may increase infection risk through immunosuppression or neutropenia, and trastuzumab raises neutropenia when given with myelosuppressive therapy. Combined use may increase the risk of infection.
What this interaction means in plain words
Tacrolimus and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tacrolimus belongs to Miscellaneous; Trastuzumab belongs to Oncology.
Why it happens
Additive pharmacodynamic effects on immune function and neutrophil counts.
What to do
Monitor blood counts and for signs of infection. Treat infections promptly and interrupt therapy if severe neutropenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Tacrolimus and Trastuzumab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Trastuzumab
Frequently asked questions
Can I take Tacrolimus with Trastuzumab?
MediHelp rates the interaction as moderate. Tacrolimus and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may increase infection risk through immunosuppression or neutropenia, and trastuzumab raises neutropenia when given with myelosuppressive therapy. Combined use may increase the risk of infection.
How serious is the interaction between Tacrolimus and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for signs of infection. Treat infections promptly and interrupt therapy if severe neutropenia occurs.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
