Drug interactions
Tacrolimus + Triamcinolone
Severity: Moderate
Tacrolimus and Triamcinolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are CYP3A4 substrates and corticosteroids may modestly alter tacrolimus exposure, but the effect is unpredictable and not well established for triamcinolone. Additive immunosuppression also raises infection risk.
What this interaction means in plain words
Tacrolimus and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tacrolimus belongs to Miscellaneous; Triamcinolone belongs to Endocrine.
Why it happens
Possible competition for or modulation of CYP3A4 metabolism, plus additive immunosuppression; the net kinetic effect is not well defined.
What to do
Monitor tacrolimus trough concentrations and renal function when starting or stopping systemic triamcinolone, and watch for infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Tacrolimus with Triamcinolone?
MediHelp rates the interaction as moderate. Tacrolimus and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are CYP3A4 substrates and corticosteroids may modestly alter tacrolimus exposure, but the effect is unpredictable and not well established for triamcinolone. Additive immunosuppression also raises infection risk.
How serious is the interaction between Tacrolimus and Triamcinolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough concentrations and renal function when starting or stopping systemic triamcinolone, and watch for infection.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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