Drug interactions
Tacrolimus + Triptorelin
Severity: Moderate
Tacrolimus and Triptorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptorelin and tacrolimus can both prolong the QT interval. Together they may increase the risk of torsades de pointes, especially with electrolyte disturbances or heart disease.
What this interaction means in plain words
Tacrolimus and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tacrolimus belongs to Miscellaneous; Triptorelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check ECG at baseline and during therapy and correct hypokalemia and hypomagnesemia. Monitor tacrolimus trough levels as usual and avoid further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triptorelin
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Tacrolimus with Triptorelin?
MediHelp rates the interaction as moderate. Tacrolimus and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptorelin and tacrolimus can both prolong the QT interval. Together they may increase the risk of torsades de pointes, especially with electrolyte disturbances or heart disease.
How serious is the interaction between Tacrolimus and Triptorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG at baseline and during therapy and correct hypokalemia and hypomagnesemia. Monitor tacrolimus trough levels as usual and avoid further QT-prolonging drugs.
What other medicines interact with Triptorelin?
MediHelp also lists interactions of Triptorelin with, for example, Amisulpride, Arsenic trioxide, Bedaquiline. The full list is on the Triptorelin page.
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