Drug interactions
Tacrolimus + Ublituximab
Severity: Moderate
Tacrolimus and Ublituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ublituximab depletes B cells and tacrolimus suppresses T cells, so combined use increases the risk of serious infections. Vaccine responses are also reduced.
What this interaction means in plain words
Tacrolimus and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tacrolimus belongs to Miscellaneous; Ublituximab belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic immunosuppression from anti-CD20 B-cell depletion and calcineurin inhibition.
What to do
Screen for hepatitis B and other infections before use and monitor for signs of infection during therapy. Reassess the need for both agents if infections occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Ublituximab
Frequently asked questions
Can I take Tacrolimus with Ublituximab?
MediHelp rates the interaction as moderate. Tacrolimus and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ublituximab depletes B cells and tacrolimus suppresses T cells, so combined use increases the risk of serious infections. Vaccine responses are also reduced.
How serious is the interaction between Tacrolimus and Ublituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Screen for hepatitis B and other infections before use and monitor for signs of infection during therapy. Reassess the need for both agents if infections occur.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
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