Drug interactions
Tadalafil + Tazemetostat
Severity: Moderate
Tadalafil and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak to moderate CYP3A4 inducer and may reduce tadalafil exposure. This could lessen the therapeutic effect.
What this interaction means in plain words
Tadalafil and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tadalafil belongs to Genitourinary; Tazemetostat belongs to Miscellaneous.
Why it happens
Tazemetostat induces CYP3A4, increasing tadalafil metabolism.
What to do
Monitor response to tadalafil and adjust the dose if efficacy is reduced. Be alert for rebound exposure when tazemetostat is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Tadalafil with Tazemetostat?
MediHelp rates the interaction as moderate. Tadalafil and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak to moderate CYP3A4 inducer and may reduce tadalafil exposure. This could lessen the therapeutic effect.
How serious is the interaction between Tadalafil and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response to tadalafil and adjust the dose if efficacy is reduced. Be alert for rebound exposure when tazemetostat is stopped.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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