Drug interactions
Tamoxifen + Tazemetostat
Severity: Moderate
Tamoxifen and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and a CYP3A substrate, while tamoxifen may modestly raise tazemetostat exposure. Both effects are expected to be small, though tamoxifen levels could fall slightly.
What this interaction means in plain words
Tamoxifen and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tamoxifen belongs to Endocrine; Tazemetostat belongs to Miscellaneous.
Why it happens
Tazemetostat weakly induces CYP3A4, and tamoxifen may weakly inhibit CYP3A-mediated tazemetostat metabolism.
What to do
Monitor for tazemetostat adverse effects and for reduced tamoxifen response. No empiric dose change is usually required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Tamoxifen with Tazemetostat?
MediHelp rates the interaction as moderate. Tamoxifen and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak CYP3A4 inducer and a CYP3A substrate, while tamoxifen may modestly raise tazemetostat exposure. Both effects are expected to be small, though tamoxifen levels could fall slightly.
How serious is the interaction between Tamoxifen and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tazemetostat adverse effects and for reduced tamoxifen response. No empiric dose change is usually required.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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