Drug interactions
Tamoxifen + Tipranavir
Severity: Moderate
Tamoxifen and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir/ritonavir inhibits CYP3A4, which could reduce formation of endoxifen from tamoxifen. Tipranavir also has mixed inducing effects, so net impact is unpredictable.
What this interaction means in plain words
Tamoxifen and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tamoxifen belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
CYP3A4 modulation by tipranavir/ritonavir alters tamoxifen conversion to active metabolites.
What to do
Monitor for reduced tamoxifen effectiveness and consider alternative antiretrovirals if feasible. Coordinate with the oncology and HIV teams.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Tamoxifen with Tipranavir?
MediHelp rates the interaction as moderate. Tamoxifen and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir/ritonavir inhibits CYP3A4, which could reduce formation of endoxifen from tamoxifen. Tipranavir also has mixed inducing effects, so net impact is unpredictable.
How serious is the interaction between Tamoxifen and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced tamoxifen effectiveness and consider alternative antiretrovirals if feasible. Coordinate with the oncology and HIV teams.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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