Drug interactions
Tamsulosin + Terbinafine
Severity: Moderate
Tamsulosin and Terbinafine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terbinafine is a strong CYP2D6 inhibitor and can raise tamsulosin concentrations, which are partly cleared by CYP2D6. Higher exposure may cause orthostatic hypotension, dizziness and syncope.
What this interaction means in plain words
Tamsulosin and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tamsulosin belongs to Genitourinary; Terbinafine belongs to Anti Fungals.
Why it happens
Inhibition of CYP2D6 reduces tamsulosin metabolism.
What to do
Monitor for dizziness and orthostatic hypotension, particularly during a long terbinafine course, and counsel patients on rising slowly. Consider a lower tamsulosin dose or an alternative if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Frequently asked questions
Can I take Tamsulosin with Terbinafine?
MediHelp rates the interaction as moderate. Tamsulosin and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Terbinafine is a strong CYP2D6 inhibitor and can raise tamsulosin concentrations, which are partly cleared by CYP2D6. Higher exposure may cause orthostatic hypotension, dizziness and syncope.
How serious is the interaction between Tamsulosin and Terbinafine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness and orthostatic hypotension, particularly during a long terbinafine course, and counsel patients on rising slowly. Consider a lower tamsulosin dose or an alternative if symptoms occur.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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