Drug interactions
Tamsulosin + Thioridazine
Severity: Moderate
Tamsulosin and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine inhibits CYP2D6 and also has alpha-adrenergic blocking activity, so tamsulosin exposure and hypotensive effects may both increase. Thioridazine itself carries serious QT risk, which adds to the concern in patients on multiple drugs.
What this interaction means in plain words
Tamsulosin and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tamsulosin belongs to Genitourinary; Thioridazine belongs to Central Nervous System.
Why it happens
Thioridazine inhibits CYP2D6 and adds pharmacodynamic alpha-blockade.
What to do
Monitor blood pressure and orthostatic symptoms, and reduce the tamsulosin dose if needed. Consider alternatives to thioridazine where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Tamsulosin with Thioridazine?
MediHelp rates the interaction as moderate. Tamsulosin and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thioridazine inhibits CYP2D6 and also has alpha-adrenergic blocking activity, so tamsulosin exposure and hypotensive effects may both increase. Thioridazine itself carries serious QT risk, which adds to the concern in patients on multiple drugs.
How serious is the interaction between Tamsulosin and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, and reduce the tamsulosin dose if needed. Consider alternatives to thioridazine where possible.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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