Drug interactions
Tamsulosin + Tranylcypromine
Severity: Moderate
Tamsulosin and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tranylcypromine has weak CYP2D6 inhibition, but more importantly it frequently causes orthostatic hypotension, which may be amplified by tamsulosin. The combined effect may lead to dizziness, falls or syncope.
What this interaction means in plain words
Tamsulosin and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tamsulosin belongs to Genitourinary; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects, with possible weak CYP2D6 inhibition by tranylcypromine.
What to do
Monitor supine and standing blood pressure when combining. Counsel patients to rise slowly and reduce the tamsulosin dose if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Tamsulosin and Tranylcypromine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Tamsulosin with Tranylcypromine?
MediHelp rates the interaction as moderate. Tamsulosin and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tranylcypromine has weak CYP2D6 inhibition, but more importantly it frequently causes orthostatic hypotension, which may be amplified by tamsulosin. The combined effect may lead to dizziness, falls or syncope.
How serious is the interaction between Tamsulosin and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure when combining. Counsel patients to rise slowly and reduce the tamsulosin dose if symptomatic.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
