Drug interactions
Tamsulosin + Vardenafil
Severity: Moderate
Tamsulosin and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure through vasodilation, so combining them can cause symptomatic postural hypotension, dizziness or syncope. The risk is highest when starting or increasing doses, and in older patients.
What this interaction means in plain words
Tamsulosin and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tamsulosin belongs to Genitourinary; Vardenafil belongs to Genitourinary.
Why it happens
Additive vasodilation from PDE5 inhibition and alpha-1 adrenergic blockade.
What to do
Make sure the patient is stable on the alpha-blocker before starting vardenafil, and begin with the lowest vardenafil dose. Counsel on rising slowly and monitor blood pressure and orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Frequently asked questions
Can I take Tamsulosin with Vardenafil?
MediHelp rates the interaction as moderate. Tamsulosin and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure through vasodilation, so combining them can cause symptomatic postural hypotension, dizziness or syncope. The risk is highest when starting or increasing doses, and in older patients.
How serious is the interaction between Tamsulosin and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Make sure the patient is stable on the alpha-blocker before starting vardenafil, and begin with the lowest vardenafil dose. Counsel on rising slowly and monitor blood pressure and orthostatic symptoms.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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