Drug interactions
Tapentadol + Zuranolone
Severity: Moderate
Tapentadol and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes somnolence and impaired driving ability, and opioids add to these CNS depressant effects. Concurrent use can increase sedation and psychomotor impairment.
What this interaction means in plain words
Tapentadol and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tapentadol belongs to Musculoskeletal; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A positive modulation by zuranolone and mu-opioid agonism by tapentadol.
What to do
Consider reducing the dose of zuranolone or tapentadol if sedation occurs, and counsel patients not to drive for at least 12 hours after zuranolone. Monitor for excess sedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Tapentadol with Zuranolone?
MediHelp rates the interaction as moderate. Tapentadol and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes somnolence and impaired driving ability, and opioids add to these CNS depressant effects. Concurrent use can increase sedation and psychomotor impairment.
How serious is the interaction between Tapentadol and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the dose of zuranolone or tapentadol if sedation occurs, and counsel patients not to drive for at least 12 hours after zuranolone. Monitor for excess sedation and respiratory depression.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
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