Drug interactions
Tazemetostat + Tolterodine
Severity: Minor
Tazemetostat and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and may modestly reduce plasma levels of CYP3A4 substrates such as tolterodine. Loss of antimuscarinic efficacy is possible but unlikely to be marked.
What this interaction means in plain words
Tazemetostat and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tazemetostat belongs to Miscellaneous; Tolterodine belongs to Genitourinary.
Why it happens
Weak induction of CYP3A4 by tazemetostat increases the metabolic clearance of tolterodine.
What to do
Monitor overactive bladder symptom control; increase the tolterodine dose only if efficacy is clearly lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Tazemetostat
Frequently asked questions
Can I take Tazemetostat with Tolterodine?
MediHelp rates the interaction as minor. Tazemetostat and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak CYP3A4 inducer and may modestly reduce plasma levels of CYP3A4 substrates such as tolterodine. Loss of antimuscarinic efficacy is possible but unlikely to be marked.
How serious is the interaction between Tazemetostat and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor overactive bladder symptom control; increase the tolterodine dose only if efficacy is clearly lost.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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