Drug interactions
Tazemetostat + Tolvaptan
Severity: Moderate
Tazemetostat and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A inducer and may reduce exposure to the CYP3A4 substrate tolvaptan. Reduced aquaretic effect could leave hyponatremia less well controlled.
What this interaction means in plain words
Tazemetostat and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tazemetostat belongs to Miscellaneous; Tolvaptan belongs to Endocrine.
Why it happens
Induction of CYP3A4 by tazemetostat increases tolvaptan metabolism.
What to do
Monitor serum sodium and clinical response, and increase the tolvaptan dose if effect is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Tazemetostat with Tolvaptan?
MediHelp rates the interaction as moderate. Tazemetostat and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak-to-moderate CYP3A inducer and may reduce exposure to the CYP3A4 substrate tolvaptan. Reduced aquaretic effect could leave hyponatremia less well controlled.
How serious is the interaction between Tazemetostat and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and clinical response, and increase the tolvaptan dose if effect is inadequate.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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