Drug interactions
Tazemetostat + Vinorelbine
Severity: Minor
Tazemetostat and Vinorelbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and is itself metabolized by CYP3A4. Vinorelbine exposure could fall slightly, while any effect of vinorelbine on tazemetostat is poorly established.
What this interaction means in plain words
Tazemetostat and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tazemetostat belongs to Miscellaneous; Vinorelbine belongs to Oncology.
Why it happens
Weak CYP3A4 induction by tazemetostat may increase vinorelbine metabolism.
What to do
No routine dose change is needed. Monitor for reduced efficacy of vinorelbine and for overall toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vinorelbine
Other interactions of Tazemetostat
Frequently asked questions
Can I take Tazemetostat with Vinorelbine?
MediHelp rates the interaction as minor. Tazemetostat and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak CYP3A4 inducer and is itself metabolized by CYP3A4. Vinorelbine exposure could fall slightly, while any effect of vinorelbine on tazemetostat is poorly established.
How serious is the interaction between Tazemetostat and Vinorelbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for reduced efficacy of vinorelbine and for overall toxicity.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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