Drug interactions
Tecovirimat + Tretinoin
Severity: Minor
Tecovirimat and Tretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak CYP2C8 and CYP2C19 inhibitor and may slightly raise tretinoin exposure. Clinically significant effects are unlikely, though retinoid adverse effects could be marginally increased.
What this interaction means in plain words
Tecovirimat and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tecovirimat belongs to Miscellaneous; Tretinoin belongs to Dermatology.
Why it happens
Weak inhibition of CYP2C8/CYP2C19 by tecovirimat reduces tretinoin metabolism.
What to do
No dose change typically needed; monitor for retinoid adverse effects during the short tecovirimat course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Tecovirimat with Tretinoin?
MediHelp rates the interaction as minor. Tecovirimat and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat is a weak CYP2C8 and CYP2C19 inhibitor and may slightly raise tretinoin exposure. Clinically significant effects are unlikely, though retinoid adverse effects could be marginally increased.
How serious is the interaction between Tecovirimat and Tretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change typically needed; monitor for retinoid adverse effects during the short tecovirimat course.
What other medicines interact with Tretinoin?
MediHelp also lists interactions of Tretinoin with, for example, Doxycycline, Minocycline, Omadacycline. The full list is on the Tretinoin page.
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