Drug interactions
Tecovirimat + Vinorelbine
Severity: Minor
Tecovirimat and Vinorelbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak CYP3A4 inducer and may modestly lower vinorelbine concentrations. The clinical impact is likely small.
What this interaction means in plain words
Tecovirimat and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tecovirimat belongs to Miscellaneous; Vinorelbine belongs to Oncology.
Why it happens
Weak induction of CYP3A4 by tecovirimat increases vinorelbine clearance.
What to do
No dose adjustment is generally needed. Monitor for reduced vinorelbine effectiveness during the short course of tecovirimat.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vinorelbine
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Tecovirimat with Vinorelbine?
MediHelp rates the interaction as minor. Tecovirimat and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat is a weak CYP3A4 inducer and may modestly lower vinorelbine concentrations. The clinical impact is likely small.
How serious is the interaction between Tecovirimat and Vinorelbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Monitor for reduced vinorelbine effectiveness during the short course of tecovirimat.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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