Drug interactions
Tedizolid + Tyramine
Severity: Minor
Tedizolid and Tyramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tyramine is a dietary pressor amine normally broken down by MAO in the gut and liver. MAO inhibitors can allow it to cause hypertensive reactions, though tedizolid's weak inhibition makes this less likely at usual dietary intake.
What this interaction means in plain words
Tedizolid and Tyramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak reversible MAO-A inhibition by tedizolid may slightly reduce tyramine breakdown, increasing pressor response.
What to do
No strict dietary restriction is generally needed, but advise avoiding very large amounts of tyramine-rich foods such as aged cheeses and cured meats. Report severe headache or palpitations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Frequently asked questions
Can I take Tedizolid with Tyramine?
MediHelp rates the interaction as minor. Tedizolid and Tyramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tyramine is a dietary pressor amine normally broken down by MAO in the gut and liver. MAO inhibitors can allow it to cause hypertensive reactions, though tedizolid's weak inhibition makes this less likely at usual dietary intake.
How serious is the interaction between Tedizolid and Tyramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No strict dietary restriction is generally needed, but advise avoiding very large amounts of tyramine-rich foods such as aged cheeses and cured meats. Report severe headache or palpitations.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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