Drug interactions
Tedizolid + Venlafaxine
Severity: Major
Tedizolid and Venlafaxine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine inhibits serotonin and norepinephrine reuptake, and tedizolid is a weak MAO inhibitor. Serotonin syndrome and blood pressure elevation are theoretical risks. Clinical data with tedizolid are limited.
What this interaction means in plain words
Tedizolid and Venlafaxine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tedizolid belongs to Anti Bacterial; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive serotonergic and noradrenergic effects from reuptake inhibition and weak MAO inhibition.
What to do
Avoid if an alternative antibiotic is suitable. If co-prescribed, monitor for serotonin toxicity and blood pressure, and stop one drug if it develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Tedizolid with Venlafaxine?
MediHelp rates the interaction as major. Tedizolid and Venlafaxine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Venlafaxine inhibits serotonin and norepinephrine reuptake, and tedizolid is a weak MAO inhibitor. Serotonin syndrome and blood pressure elevation are theoretical risks. Clinical data with tedizolid are limited.
How serious is the interaction between Tedizolid and Venlafaxine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative antibiotic is suitable. If co-prescribed, monitor for serotonin toxicity and blood pressure, and stop one drug if it develops.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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