Drug interactions
Telavancin + Trimethoprim
Severity: Moderate
Telavancin and Trimethoprim: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been linked to QTc prolongation, and the combination may add to arrhythmia risk. Trimethoprim can also cause hyperkalemia and renal effects that complicate the picture.
What this interaction means in plain words
Telavancin and Trimethoprim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Telavancin belongs to Anti Bacterial; Trimethoprim belongs to Anti Bacterial.
Why it happens
Possible additive QT prolongation.
What to do
Check ECG, potassium and renal function at baseline in at-risk patients. Monitor the QTc and electrolytes during concurrent use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Trimethoprim
Frequently asked questions
Can I take Telavancin with Trimethoprim?
MediHelp rates the interaction as moderate. Telavancin and Trimethoprim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been linked to QTc prolongation, and the combination may add to arrhythmia risk. Trimethoprim can also cause hyperkalemia and renal effects that complicate the picture.
How serious is the interaction between Telavancin and Trimethoprim?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG, potassium and renal function at baseline in at-risk patients. Monitor the QTc and electrolytes during concurrent use.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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