Drug interactions
Telmisartan-amlodipine + Vadadustat
Severity: Moderate
Telmisartan-amlodipine and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat is a substrate of OAT1 and OAT3, and telmisartan may inhibit these transporters. Exposure to vadadustat may rise, increasing the chance of excessive hemoglobin response and adverse effects.
What this interaction means in plain words
Telmisartan-amlodipine and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Telmisartan-amlodipine belongs to Cardiovascular; Vadadustat belongs to Endocrine.
Why it happens
Inhibition of renal OAT1/OAT3 transport reduces vadadustat clearance and increases exposure.
What to do
Monitor hemoglobin regularly after starting or changing telmisartan and adjust the vadadustat dose per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Telmisartan-amlodipine with Vadadustat?
MediHelp rates the interaction as moderate. Telmisartan-amlodipine and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat is a substrate of OAT1 and OAT3, and telmisartan may inhibit these transporters. Exposure to vadadustat may rise, increasing the chance of excessive hemoglobin response and adverse effects.
How serious is the interaction between Telmisartan-amlodipine and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin regularly after starting or changing telmisartan and adjust the vadadustat dose per labeling.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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