Drug interactions
Temsirolimus + Tetanus toxoid adsorbed or fluid
Severity: Moderate
Temsirolimus and Tetanus toxoid adsorbed or fluid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus may blunt the antibody response to tetanus toxoid, so protection after vaccination may be inadequate. The vaccine is non-live and poses no infection risk.
What this interaction means in plain words
Temsirolimus and Tetanus toxoid adsorbed or fluid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
mTOR inhibition suppresses lymphocyte proliferation and so lowers vaccine immunogenicity.
What to do
Keep tetanus boosters current before starting temsirolimus. Give tetanus immune globulin as well when treating a high-risk wound, as the response to the toxoid may be poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Temsirolimus with Tetanus toxoid adsorbed or fluid?
MediHelp rates the interaction as moderate. Temsirolimus and Tetanus toxoid adsorbed or fluid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus may blunt the antibody response to tetanus toxoid, so protection after vaccination may be inadequate. The vaccine is non-live and poses no infection risk.
How serious is the interaction between Temsirolimus and Tetanus toxoid adsorbed or fluid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep tetanus boosters current before starting temsirolimus. Give tetanus immune globulin as well when treating a high-risk wound, as the response to the toxoid may be poor.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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