Drug interactions
Temsirolimus + Tick-borne encephalitis vaccine
Severity: Moderate
Temsirolimus and Tick-borne encephalitis vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus is an mTOR inhibitor with immunosuppressive activity and may blunt the antibody response to inactivated vaccines such as tick-borne encephalitis vaccine. Protection may therefore be incomplete. The vaccine itself is not live, so there is no added infection risk from the vaccine.
What this interaction means in plain words
Temsirolimus and Tick-borne encephalitis vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
mTOR inhibition suppresses T- and B-cell proliferation and so reduces the immune response to vaccination.
What to do
Where possible, vaccinate before starting temsirolimus or during a treatment break. If vaccinated on therapy, consider checking antibody titres and revaccinating if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Temsirolimus with Tick-borne encephalitis vaccine?
MediHelp rates the interaction as moderate. Temsirolimus and Tick-borne encephalitis vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus is an mTOR inhibitor with immunosuppressive activity and may blunt the antibody response to inactivated vaccines such as tick-borne encephalitis vaccine. Protection may therefore be incomplete. The vaccine itself is not live, so there is no added infection risk from the vaccine.
How serious is the interaction between Temsirolimus and Tick-borne encephalitis vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, vaccinate before starting temsirolimus or during a treatment break. If vaccinated on therapy, consider checking antibody titres and revaccinating if the response is inadequate.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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