Drug interactions
Temsirolimus + Topiramate
Severity: Minor
Temsirolimus and Topiramate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus and its active metabolite sirolimus are CYP3A4 substrates, so induction can reduce exposure. Topiramate is a weak inducer, so the effect is expected to be limited.
What this interaction means in plain words
Temsirolimus and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Temsirolimus belongs to Oncology; Topiramate belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by topiramate may increase temsirolimus clearance.
What to do
No routine dose change; monitor clinical response and consider alternatives if a strong inducer would be needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Topiramate
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Temsirolimus with Topiramate?
MediHelp rates the interaction as minor. Temsirolimus and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Temsirolimus and its active metabolite sirolimus are CYP3A4 substrates, so induction can reduce exposure. Topiramate is a weak inducer, so the effect is expected to be limited.
How serious is the interaction between Temsirolimus and Topiramate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor clinical response and consider alternatives if a strong inducer would be needed.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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