Drug interactions
Temsirolimus + Travelers diarrhea and cholera vaccine inactivated
Severity: Moderate
Temsirolimus and Travelers diarrhea and cholera vaccine inactivated: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus may reduce the immune response to an inactivated oral cholera/travelers diarrhea vaccine, leaving the patient less protected. The vaccine is non-replicating, so the concern is reduced efficacy rather than infection.
What this interaction means in plain words
Temsirolimus and Travelers diarrhea and cholera vaccine inactivated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
mTOR inhibition impairs lymphocyte proliferation and antibody production.
What to do
Complete vaccination before temsirolimus where feasible. Otherwise vaccinate anyway and reinforce food and water hygiene precautions, since protection may be reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Temsirolimus with Travelers diarrhea and cholera vaccine inactivated?
MediHelp rates the interaction as moderate. Temsirolimus and Travelers diarrhea and cholera vaccine inactivated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus may reduce the immune response to an inactivated oral cholera/travelers diarrhea vaccine, leaving the patient less protected. The vaccine is non-replicating, so the concern is reduced efficacy rather than infection.
How serious is the interaction between Temsirolimus and Travelers diarrhea and cholera vaccine inactivated?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete vaccination before temsirolimus where feasible. Otherwise vaccinate anyway and reinforce food and water hygiene precautions, since protection may be reduced.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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