Drug interactions
Temsirolimus + Typhoid polysaccharide vaccine
Severity: Moderate
Temsirolimus and Typhoid polysaccharide vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus can diminish the antibody response to the inactivated Vi typhoid polysaccharide vaccine. Protection against typhoid may be lower than expected in treated patients.
What this interaction means in plain words
Temsirolimus and Typhoid polysaccharide vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
mTOR inhibition suppresses immune cell proliferation and humoral responses.
What to do
Give the vaccine at least 2 weeks before starting temsirolimus if possible. Continue food and water precautions during travel.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Temsirolimus with Typhoid polysaccharide vaccine?
MediHelp rates the interaction as moderate. Temsirolimus and Typhoid polysaccharide vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus can diminish the antibody response to the inactivated Vi typhoid polysaccharide vaccine. Protection against typhoid may be lower than expected in treated patients.
How serious is the interaction between Temsirolimus and Typhoid polysaccharide vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine at least 2 weeks before starting temsirolimus if possible. Continue food and water precautions during travel.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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