Drug interactions
Temsirolimus + Typhoid vaccine live
Severity: Contraindicated
Temsirolimus and Typhoid vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live attenuated oral typhoid vaccine given to a patient on temsirolimus may cause disseminated infection from the vaccine strain because of impaired immunity. The vaccine response may also be poor.
What this interaction means in plain words
Temsirolimus and Typhoid vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
mTOR inhibition-related immunosuppression permits uncontrolled replication of live attenuated organisms.
What to do
Do not give live typhoid vaccine during temsirolimus therapy. Use the inactivated injectable Vi vaccine instead.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Temsirolimus with Typhoid vaccine live?
MediHelp rates the interaction as contraindicated. Temsirolimus and Typhoid vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live attenuated oral typhoid vaccine given to a patient on temsirolimus may cause disseminated infection from the vaccine strain because of impaired immunity. The vaccine response may also be poor.
How serious is the interaction between Temsirolimus and Typhoid vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live typhoid vaccine during temsirolimus therapy. Use the inactivated injectable Vi vaccine instead.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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