Drug interactions
Temsirolimus + Yellow fever vaccine
Severity: Contraindicated
Temsirolimus and Yellow fever vaccine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yellow fever vaccine is a live attenuated vaccine and may cause serious disseminated or neurotropic disease in patients immunosuppressed by temsirolimus. The immune response may also be inadequate.
What this interaction means in plain words
Temsirolimus and Yellow fever vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Immunosuppression from mTOR inhibition permits uncontrolled replication of the live vaccine virus.
What to do
Avoid the vaccine during temsirolimus treatment and advise against travel to endemic areas. If travel is unavoidable, provide a medical exemption letter and mosquito-protection advice.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Temsirolimus with Yellow fever vaccine?
MediHelp rates the interaction as contraindicated. Temsirolimus and Yellow fever vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Yellow fever vaccine is a live attenuated vaccine and may cause serious disseminated or neurotropic disease in patients immunosuppressed by temsirolimus. The immune response may also be inadequate.
How serious is the interaction between Temsirolimus and Yellow fever vaccine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the vaccine during temsirolimus treatment and advise against travel to endemic areas. If travel is unavoidable, provide a medical exemption letter and mosquito-protection advice.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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