Drug interactions
Temsirolimus + Zoster vaccine recombinant
Severity: Moderate
Temsirolimus and Zoster vaccine recombinant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppression from temsirolimus may blunt the immune response to the recombinant zoster vaccine. Because this vaccine is non-live, it is not a infection risk, but protection may be lower.
What this interaction means in plain words
Temsirolimus and Zoster vaccine recombinant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
mTOR inhibition suppresses T-cell proliferation and so reduces vaccine immunogenicity.
What to do
Where feasible, vaccinate before starting temsirolimus or during a treatment break. Do not withhold vaccination if timing cannot be adjusted, as the non-live vaccine is safe.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Temsirolimus with Zoster vaccine recombinant?
MediHelp rates the interaction as moderate. Temsirolimus and Zoster vaccine recombinant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Immunosuppression from temsirolimus may blunt the immune response to the recombinant zoster vaccine. Because this vaccine is non-live, it is not a infection risk, but protection may be lower.
How serious is the interaction between Temsirolimus and Zoster vaccine recombinant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where feasible, vaccinate before starting temsirolimus or during a treatment break. Do not withhold vaccination if timing cannot be adjusted, as the non-live vaccine is safe.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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