Drug interactions
Tenecteplase + Tranexamic acid
Severity: Moderate
Tenecteplase and Tranexamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenecteplase is a fibrin-specific plasminogen activator, and tranexamic acid is an antifibrinolytic that prevents plasmin from acting on fibrin. Together they oppose one another and clot lysis may be diminished. Tranexamic acid can be used purposefully to reverse thrombolytic-related bleeding.
What this interaction means in plain words
Tenecteplase and Tranexamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tenecteplase belongs to Cardiovascular; Tranexamic acid belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism: tranexamic acid blocks plasminogen lysine-binding sites, limiting fibrinolysis induced by tenecteplase.
What to do
Avoid concurrent use when thrombolysis is intended. If used to treat major bleeding after tenecteplase, monitor for recurrent thrombosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranexamic acid
- Dienogest / estradiol valerate + Tranexamic acid Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Ethinylestradiol + Tranexamic acid Contraindicated
- Mestranol + Tranexamic acid Contraindicated
Other interactions of Tenecteplase
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Tenecteplase Major
- Apixaban + Tenecteplase Major
- Argatroban + Tenecteplase Major
- Dabigatran etexilate + Tenecteplase Major
- Dalteparin + Tenecteplase Major
Frequently asked questions
Can I take Tenecteplase with Tranexamic acid?
MediHelp rates the interaction as moderate. Tenecteplase and Tranexamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenecteplase is a fibrin-specific plasminogen activator, and tranexamic acid is an antifibrinolytic that prevents plasmin from acting on fibrin. Together they oppose one another and clot lysis may be diminished. Tranexamic acid can be used purposefully to reverse thrombolytic-related bleeding.
How serious is the interaction between Tenecteplase and Tranexamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when thrombolysis is intended. If used to treat major bleeding after tenecteplase, monitor for recurrent thrombosis.
What other medicines interact with Tranexamic acid?
MediHelp also lists interactions of Tranexamic acid with, for example, Dienogest / estradiol valerate, Ethinyl estradiol-drospirenone, Ethinyl estradiol-levonorgestrel. The full list is on the Tranexamic acid page.
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