Drug interactions
Tenofovir disoproxil + Vadadustat
Severity: Minor
Tenofovir disoproxil and Vadadustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits BCRP and may raise exposure to BCRP substrates. Tenofovir is a minor BCRP substrate, so any increase is likely small.
What this interaction means in plain words
Tenofovir disoproxil and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
BCRP inhibition by vadadustat may increase tenofovir absorption.
What to do
No empiric dose change is needed; monitor renal function as routine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Tenofovir disoproxil with Vadadustat?
MediHelp rates the interaction as minor. Tenofovir disoproxil and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vadadustat inhibits BCRP and may raise exposure to BCRP substrates. Tenofovir is a minor BCRP substrate, so any increase is likely small.
How serious is the interaction between Tenofovir disoproxil and Vadadustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed; monitor renal function as routine.
What other medicines interact with Vadadustat?
MediHelp also lists interactions of Vadadustat with, for example, Atorvastatin, Balsalazide, Baricitinib. The full list is on the Vadadustat page.
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