Drug interactions
Terbinafine + Tolbutamide
Severity: Minor
Terbinafine and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolbutamide is not a meaningful inhibitor of terbinafine metabolism. Terbinafine itself has little effect on CYP2C9 substrates, so no clinically important interaction is expected.
What this interaction means in plain words
Terbinafine and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Terbinafine belongs to Anti Fungals; Tolbutamide belongs to Endocrine.
Why it happens
No established mechanism; competition for CYP2C9 is theoretical and not clinically significant.
What to do
No action is needed beyond routine blood glucose monitoring in diabetic patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Terbinafine with Tolbutamide?
MediHelp rates the interaction as minor. Terbinafine and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolbutamide is not a meaningful inhibitor of terbinafine metabolism. Terbinafine itself has little effect on CYP2C9 substrates, so no clinically important interaction is expected.
How serious is the interaction between Terbinafine and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond routine blood glucose monitoring in diabetic patients.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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