Drug interactions
Terbutaline + Tiotropium-olodaterol
Severity: Moderate
Terbutaline and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terbutaline is a beta2 agonist, so combining it with olodaterol duplicates beta-adrenergic stimulation. This can cause tachycardia, tremor, hypokalemia, palpitations and arrhythmia, especially with oral or injected terbutaline.
What this interaction means in plain words
Terbutaline and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Terbutaline belongs to Respiratory; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive beta2-adrenergic receptor agonism.
What to do
Avoid routine concurrent use of two beta2 agonists; if both are needed, monitor heart rate, tremor and serum potassium and review the need for the additional agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Terbutaline and Tiotropium-olodaterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tiotropium-olodaterol
Other interactions of Terbutaline
Frequently asked questions
Can I take Terbutaline with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Terbutaline and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Terbutaline is a beta2 agonist, so combining it with olodaterol duplicates beta-adrenergic stimulation. This can cause tachycardia, tremor, hypokalemia, palpitations and arrhythmia, especially with oral or injected terbutaline.
How serious is the interaction between Terbutaline and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use of two beta2 agonists; if both are needed, monitor heart rate, tremor and serum potassium and review the need for the additional agent.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
