Drug interactions
Tetanus immune globulin + Varicella virus vaccine live
Severity: Moderate
Tetanus immune globulin and Varicella virus vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibody-containing blood products can reduce the take of live varicella vaccine and lead to inadequate immunity. Tetanus immune globulin contains a relatively low amount of other antibodies compared with products such as VZIG, so the effect is uncertain.
What this interaction means in plain words
Tetanus immune globulin and Varicella virus vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Passive antibodies may neutralize the replicating vaccine virus, impairing the active immune response.
What to do
Follow national immunization schedules for the interval after immune globulin before giving varicella vaccine. Consider checking immunity or revaccinating if the vaccine was given too soon.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tetanus immune globulin
- Efgartigimod / hyaluronidase sc + Tetanus immune globulin Moderate
- Efgartigimod alfa + Tetanus immune globulin Moderate
- Rozanolixizumab + Tetanus immune globulin Moderate
- Measles mumps and rubella vaccine live + Tetanus immune globulin Minor
- Measles mumps and rubella vaccine + Tetanus immune globulin Minor
- Measles mumps rubella and varicella vaccine live + Tetanus immune globulin Minor
Frequently asked questions
Can I take Tetanus immune globulin with Varicella virus vaccine live?
MediHelp rates the interaction as moderate. Tetanus immune globulin and Varicella virus vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antibody-containing blood products can reduce the take of live varicella vaccine and lead to inadequate immunity. Tetanus immune globulin contains a relatively low amount of other antibodies compared with products such as VZIG, so the effect is uncertain.
How serious is the interaction between Tetanus immune globulin and Varicella virus vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow national immunization schedules for the interval after immune globulin before giving varicella vaccine. Consider checking immunity or revaccinating if the vaccine was given too soon.
What other medicines interact with Tetanus immune globulin?
MediHelp also lists interactions of Tetanus immune globulin with, for example, Efgartigimod / hyaluronidase sc, Efgartigimod alfa, Rozanolixizumab. The full list is on the Tetanus immune globulin page.
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