Drug interactions
Measles mumps and rubella vaccine + Tetanus immune globulin
Severity: Minor
Measles mumps and rubella vaccine and Tetanus immune globulin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibodies in tetanus immune globulin may reduce the immune response to live MMR vaccine, though the effect is smaller than with preparations with high measles antibody content. Protection may be incomplete if timing is not considered.
What this interaction means in plain words
Measles mumps and rubella vaccine and Tetanus immune globulin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Measles mumps and rubella vaccine belongs to Miscellaneous; Tetanus immune globulin belongs to Miscellaneous.
Why it happens
Passive antibodies may partially neutralise live vaccine virus replication.
What to do
Follow local immunisation guidance on spacing; routine tetanus immune globulin is not generally thought to need a long delay before MMR, but verify the schedule for your jurisdiction. Revaccinate if seroprotection is in doubt.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Other interactions of Tetanus immune globulin
- Efgartigimod / hyaluronidase sc + Tetanus immune globulin Moderate
- Efgartigimod alfa + Tetanus immune globulin Moderate
- Rozanolixizumab + Tetanus immune globulin Moderate
- Tetanus immune globulin + Varicella virus vaccine live Moderate
- Measles mumps and rubella vaccine live + Tetanus immune globulin Minor
- Measles mumps rubella and varicella vaccine live + Tetanus immune globulin Minor
Frequently asked questions
Can I take Measles mumps and rubella vaccine with Tetanus immune globulin?
MediHelp rates the interaction as minor. Measles mumps and rubella vaccine and Tetanus immune globulin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibodies in tetanus immune globulin may reduce the immune response to live MMR vaccine, though the effect is smaller than with preparations with high measles antibody content. Protection may be incomplete if timing is not considered.
How serious is the interaction between Measles mumps and rubella vaccine and Tetanus immune globulin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow local immunisation guidance on spacing; routine tetanus immune globulin is not generally thought to need a long delay before MMR, but verify the schedule for your jurisdiction. Revaccinate if seroprotection is in doubt.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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