Drug interactions
Efgartigimod alfa + Tetanus immune globulin
Severity: Moderate
Efgartigimod alfa and Tetanus immune globulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efgartigimod blocks the neonatal Fc receptor and lowers circulating IgG. Tetanus immune globulin is IgG, so its levels may fall faster and protection in a tetanus-prone wound may be shorter.
What this interaction means in plain words
Efgartigimod alfa and Tetanus immune globulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efgartigimod alfa belongs to Miscellaneous; Tetanus immune globulin belongs to Miscellaneous.
Why it happens
Neonatal Fc receptor blockade increases catabolism of exogenous IgG.
What to do
Give TIG and tetanus toxoid as indicated for wound management and consider antitoxin titers or repeat dosing if the wound risk is high. Watch closely for early signs of tetanus.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tetanus immune globulin
- Efgartigimod / hyaluronidase sc + Tetanus immune globulin Moderate
- Rozanolixizumab + Tetanus immune globulin Moderate
- Tetanus immune globulin + Varicella virus vaccine live Moderate
- Measles mumps and rubella vaccine live + Tetanus immune globulin Minor
- Measles mumps and rubella vaccine + Tetanus immune globulin Minor
- Measles mumps rubella and varicella vaccine live + Tetanus immune globulin Minor
Other interactions of Efgartigimod alfa
- Adalimumab + Efgartigimod alfa Moderate
- Ado-trastuzumab + Efgartigimod alfa Moderate
- Basiliximab + Efgartigimod alfa Moderate
- Bevacizumab + Efgartigimod alfa Moderate
- Brentuximab + Efgartigimod alfa Moderate
- Denosumab + Efgartigimod alfa Moderate
Frequently asked questions
Can I take Efgartigimod alfa with Tetanus immune globulin?
MediHelp rates the interaction as moderate. Efgartigimod alfa and Tetanus immune globulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efgartigimod blocks the neonatal Fc receptor and lowers circulating IgG. Tetanus immune globulin is IgG, so its levels may fall faster and protection in a tetanus-prone wound may be shorter.
How serious is the interaction between Efgartigimod alfa and Tetanus immune globulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give TIG and tetanus toxoid as indicated for wound management and consider antitoxin titers or repeat dosing if the wound risk is high. Watch closely for early signs of tetanus.
What other medicines interact with Tetanus immune globulin?
MediHelp also lists interactions of Tetanus immune globulin with, for example, Efgartigimod / hyaluronidase sc, Rozanolixizumab, Varicella virus vaccine live. The full list is on the Tetanus immune globulin page.
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