Drug interactions
Rozanolixizumab + Tetanus immune globulin
Severity: Moderate
Rozanolixizumab and Tetanus immune globulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rozanolixizumab blocks the neonatal Fc receptor and lowers circulating IgG. Tetanus immune globulin is IgG, so its levels may fall faster and protection in a tetanus-prone wound may be shorter.
What this interaction means in plain words
Rozanolixizumab and Tetanus immune globulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rozanolixizumab belongs to Miscellaneous; Tetanus immune globulin belongs to Miscellaneous.
Why it happens
Neonatal Fc receptor blockade increases catabolism of exogenous IgG.
What to do
Give TIG and tetanus toxoid as indicated for wound management and consider antitoxin titers or repeat dosing if the wound risk is high. Watch closely for early signs of tetanus.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Rozanolixizumab and Tetanus immune globulin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tetanus immune globulin
- Efgartigimod / hyaluronidase sc + Tetanus immune globulin Moderate
- Efgartigimod alfa + Tetanus immune globulin Moderate
- Tetanus immune globulin + Varicella virus vaccine live Moderate
- Measles mumps and rubella vaccine live + Tetanus immune globulin Minor
- Measles mumps and rubella vaccine + Tetanus immune globulin Minor
- Measles mumps rubella and varicella vaccine live + Tetanus immune globulin Minor
Other interactions of Rozanolixizumab
- Rozanolixizumab + Upadacitinib Major
- Abatacept + Rozanolixizumab Moderate
- Adalimumab + Rozanolixizumab Moderate
- Ado-trastuzumab + Rozanolixizumab Moderate
- Basiliximab + Rozanolixizumab Moderate
- Bevacizumab + Rozanolixizumab Moderate
Frequently asked questions
Can I take Rozanolixizumab with Tetanus immune globulin?
MediHelp rates the interaction as moderate. Rozanolixizumab and Tetanus immune globulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rozanolixizumab blocks the neonatal Fc receptor and lowers circulating IgG. Tetanus immune globulin is IgG, so its levels may fall faster and protection in a tetanus-prone wound may be shorter.
How serious is the interaction between Rozanolixizumab and Tetanus immune globulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give TIG and tetanus toxoid as indicated for wound management and consider antitoxin titers or repeat dosing if the wound risk is high. Watch closely for early signs of tetanus.
What other medicines interact with Tetanus immune globulin?
MediHelp also lists interactions of Tetanus immune globulin with, for example, Efgartigimod / hyaluronidase sc, Efgartigimod alfa, Varicella virus vaccine live. The full list is on the Tetanus immune globulin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
