Drug interactions
Thalidomide + Vedolizumab
Severity: Moderate
Thalidomide and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thalidomide is an immunomodulatory agent with some effects on infection risk and neutropenia. Combined with vedolizumab, the infection risk may rise, though vedolizumab's gut selectivity makes a large additive effect unlikely and there is little direct data.
What this interaction means in plain words
Thalidomide and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Thalidomide belongs to Miscellaneous; Vedolizumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunomodulation; thalidomide modulates cytokines and T-cell function while vedolizumab blocks gut lymphocyte trafficking.
What to do
Monitor for infections, including opportunistic and enteric ones, and check blood counts periodically. Reassess the need for each drug if infections occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Other interactions of Thalidomide
Frequently asked questions
Can I take Thalidomide with Vedolizumab?
MediHelp rates the interaction as moderate. Thalidomide and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thalidomide is an immunomodulatory agent with some effects on infection risk and neutropenia. Combined with vedolizumab, the infection risk may rise, though vedolizumab's gut selectivity makes a large additive effect unlikely and there is little direct data.
How serious is the interaction between Thalidomide and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infections, including opportunistic and enteric ones, and check blood counts periodically. Reassess the need for each drug if infections occur.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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