Drug interactions
Theophylline + Tiotropium-olodaterol
Severity: Moderate
Theophylline and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both olodaterol and theophylline can lower serum potassium and stimulate the heart. Together they may increase the risk of hypokalemia, tachyarrhythmias and palpitations, especially during acute illness or hypoxia.
What this interaction means in plain words
Theophylline and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Theophylline belongs to Respiratory; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive beta2-mediated intracellular potassium shift and additive cardiac stimulation.
What to do
Monitor serum potassium and heart rhythm, and check theophylline levels to avoid toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Frequently asked questions
Can I take Theophylline with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Theophylline and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both olodaterol and theophylline can lower serum potassium and stimulate the heart. Together they may increase the risk of hypokalemia, tachyarrhythmias and palpitations, especially during acute illness or hypoxia.
How serious is the interaction between Theophylline and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and heart rhythm, and check theophylline levels to avoid toxicity.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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