Drug interactions
Thiothixene + Tiotropium-olodaterol
Severity: Moderate
Thiothixene and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiothixene is an antipsychotic with anticholinergic properties and can prolong the QT interval. With tiotropium and olodaterol it can add to anticholinergic effects and cardiac arrhythmia risk.
What this interaction means in plain words
Thiothixene and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic activity and additive QT prolongation with beta2-agonist cardiac stimulation.
What to do
Monitor for anticholinergic symptoms and palpitations, and check ECG if other QT risk factors exist. Correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Frequently asked questions
Can I take Thiothixene with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Thiothixene and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiothixene is an antipsychotic with anticholinergic properties and can prolong the QT interval. With tiotropium and olodaterol it can add to anticholinergic effects and cardiac arrhythmia risk.
How serious is the interaction between Thiothixene and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms and palpitations, and check ECG if other QT risk factors exist. Correct electrolyte abnormalities.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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