Drug interactions
Thiothixene + Tramadol
Severity: Moderate
Thiothixene and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining tramadol with the antipsychotic thiothixene can increase sedation and psychomotor impairment. Both drugs also lower the seizure threshold, so seizure risk may rise.
What this interaction means in plain words
Thiothixene and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and additive lowering of the seizure threshold.
What to do
Use the lowest effective doses and monitor for oversedation and seizures. Counsel patients about driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Thiothixene with Tramadol?
MediHelp rates the interaction as moderate. Thiothixene and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining tramadol with the antipsychotic thiothixene can increase sedation and psychomotor impairment. Both drugs also lower the seizure threshold, so seizure risk may rise.
How serious is the interaction between Thiothixene and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and seizures. Counsel patients about driving and operating machinery.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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